Light on Longevity

Scientists can create fruit flies that live a 250% longer life span. We are also finding many ways to get old human cells to behave as young ones do. “Unless ye be as little children, you cannot enter the Kingdom of Heaven,” so let's get started on our second childhood, right away. You’ll not only have more fun in your function, but you’ll also likely enjoy living longer as well…

Attitude: Gratitude. Don’t worry, be happy. A study of 1,500 centenarians found that diets, activity levels, and smoking habits varied widely, but nearly all have a good sense of humor and don’t worry.

Diet

Calorie restriction is crucial. The best way to restrict calories is to focus your diet on greens and vegetables and minimize commercial, refined, and processed foods, sugars, and carbohydrates. Make sure you get an adequate balance of protein, but not an excess. The common American diet contains 4 times the optimal protein. Reduce calories to about two-thirds of what it takes to maintain your normal weight if you are at all overweight. Initial weight loss tapers off as your metabolism adjusts to a lower metabolic rate. Get plenty of antioxidants in your diet to prevent free-radical damage. Occasionally enjoy no sulfite added wines if tolerated and eat lots of berries. See below for specific antioxidant nutrients.

Keep homocysteine low. High levels of homocysteine correlate strongly with most degenerative diseases of aging, especially heart attacks and strokes. You can check your homocysteine level with a blood test if you want. You can lower homocysteine by eating raw fresh organic dark leafy greens and taking methyl donors, the most commonly deficient vitamin group on commercial food diets.

Avoid sugar and minimize grains.

Botanicals

Resveratrol from grapes (Vitis vinifera) or giant knotweed (Polygonum cuspidatum) extends the life of yeast (Saccharomyces cerevisiae) cells by 70% via a niacin-dependent enzyme, Sir2. Humans have a homologous enzyme SIRT1, a deacetylase. Resveratrol works synergistically with Quercetin (water-soluble Quercetin is best absorbed). Resveratrol is found in wine, with white wine containing only about 10% of red’s 200 to 5,000 mcg per glass.

Polygonum multiflorum (Fo ti, Ho Shou Wu, Japanese knotweed) and Centella asiatica (gotu kola) are thought to extend longevity. Polygonum multiflorum is said to contain Vitamin X. Pharmacology studies show that an extract improves the cardiovascular system, enhances immune functions, slows the degeneration of glands, increases antioxidant activity, and reduces the accumulation of lipid peroxidation.

Chen Keji and Zhang Wenpeng, Advances on antiaging herbal medicines in China , Abstracts of Chinese Medicine 1987; 1(2): 309-330.

Processed Polygonum multiflorum affects the antioxidant enzyme superoxide dismutase (SOD), accumulation of lipid peroxidase, and enhances cellular immunity, while the unprocessed herb is much less effective.

Ye Dingjiang, et al., Immunopharmacological studies of ho-shou-wu and its preparations, 1987 Bulletin of Chinese Materia Medica 12(3): 21-24.

Pan Hongping, Wang Hong, and He Tingcai, Processed root tuber of Polygonum multiflorum on SOD and LPO levels in mice, China Journal of Chinese Materia Medica 1993; 18(6): 344.

Among the Chinese herbal prescriptions tested and shown useful for lowering the risk factors associated with aging and death, were (15):

• Shou Xing Bu Zhi: with main components ho-shou-wu, dioscorea, rehmannia, codonopsis (or ginseng)
• Essence Restoring Decoction: with main components ho-shou-wu, rehmannia, cuscuta, astragalus, achyranthes, and cynomorium.
• Rejuvenating Decoction: with main ingredients ho-shou-wu, astragalus, and salvia.
• Other antiaging botanicals studied extensively include:
• Panax quinquifolia (ginseng)
• Astragalus (astragalus)
• (dong quai, tang-kuei)
• epimedium
• cordyceps
• ganoderma
• Eleutherococcus senticosus (Siberian ginseng, eleuthero ginseng)
• polygonatum (huangjing).

Medicine

Avoid conventional medicine: Mortality rates are 2 to 5% higher in regions that spend more on conventional medicine, comparing areas with the same level of health. Every time physicians and surgeons go on strike, the death rate drops until they go back to work. This has been documented in Israel, California, South America, and elsewhere.

Gerovital: GH3: Ana Aslan’s clinic in Romania has treated tens of thousands of people by injection. Drug-free GH3 is now available in oral form.

Live Fetal Lamb Cells: over 50,000 patients have been treated at Clinic La Prairie in Switzerland with fresh fetal lamb cell injections.

Spirit Minerals

M-state minerals: Human blood typically lives only about 10 minutes out of the body, but in rare cases stays alive for hours or even days. One alchemist and his partner found their blood stayed alive for three days after years of ingesting m-state minerals. This effect is only found in one out of thousands of samples, usually in those with strong spirituality.

Nutrition

Vitamin C: supplementation of at least 750 to 1,000 mg twice a day is recommended. Consider fat-soluble vitamin C (Ascorbyl Palmitate) which is a form of the antioxidant that gets into the cell membranes that are highly sensitive to oxidation, and Ester C, which gets into the cytoplasm twice as well as ascorbic acid and stays in the cells twice as long.

CoQ10: protects against heart disease. Having a high CoQ10 level and a low homocysteine level keeps you out of the Emergency Room. Consider taking 100 mg of CoQ10 daily if you are in Phase 1 or have a high heart risk. Blood levels can be monitored if necessary.

L-Carnosine: Physiological concentrations (20-30 micromoles) in standard media prolong the in-vitro life span of human fibroblast cells and strongly reduce the normal features of senescence (aging). In laboratory studies, carnosine clearly improves the external appearance of animals and produces beneficial effects on behavior and average life span. Benefits include:

• most effective natural glycation fighter
• protects proteins from AGE toxicity
• extends lifespan 20 % in senescence-accelerated mice
• dramatically improves behavior and appearance of old mice
• rejuvenates senescent human cells in culture
• increases cell life span
• restores youthful appearance and growth patterns to cells approaching senescence

Alpha Lipoic Acid & Acetyl L-Carnitine:

Age-Related Mitochondrial Decay Increases Oxidative Stress in the Aging Rat Heart: Improvement by Acetylcarnitine and/or (R)-A-Lipoic Acid

T.M. Hagen and R. Moreau

Department of Biochemistry and Biophysics and the Linus Pauling Institute, Oregon State University

Mitochondria are critical to cell function. They are the site of energy production for the cell and play a critical role in cellular calcium balance. They also serve as a “gatekeeper” for apoptosis (self-induced cell death). Mitochondria are both the source and the target of reactive oxygen species, which induce oxidative damage leading to energy deficits, metabolic upset, and ultimately cell death.

We compared mitochondrial function in isolated heart, liver, and brain cells of young and old rats. Energy production and electron transport efficiency were decreased in the cells from the old animals. Cardiolipin, a substance needed for proper mitochondrial function, was reduced by 52% in the old rats. A similar decrease occurred in ubiquinone, an important component of mitochondrial energy production. The older rats also had decreased concentrations of carnitine, a substance that transports fatty acids into the mitochondria for energy production.

We evaluated the antioxidant status of the liver and heart cells. Total cell glutathione level in the old rats was reduced by about 40% compared to the levels in younger rats. Mitochondrial glutathione was reduced by 79% in the old rats, possibly due to additional oxidative stress with age. The ascorbate (vitamin C) content of both the heart and liver cells from the old rats was reduced by half in the older rats. This may indicate an increased rate of ascorbate utilization or a decreased rate of uptake. Iron content was significantly increased in the brain cells from the old rats. These age-related changes in antioxidant status and iron content create a favorable environment for the production of dangerous free radicals.

Acetylcarnitine is a naturally occurring compound used to shuttle fatty acids to the mitochondria, where they are converted to energy. It may also increase neurotransmitter levels, such as acetylcholine.

To test whether acetylcarnitine supplementation improved mitochondrial function in old rats, we fed an acetylcarnitine-supplemented diet to young and old rats. Acetylcarnitine caused certain mitochondrial membrane properties in the old animals to improve to the level observed in young animals. Supplementation also increased or restored the cardiolipin content in liver cells obtained from old rats, but did not restore cell ascorbate content.

Lipoic acid is another naturally occurring antioxidant compound that stimulates the production of glutathione. It is considered to have better antioxidant capabilities than even ascorbate.

To test the effect of lipoic acid on aging, we fed a lipoic acid-supplemented diet to young and old rats for two weeks. In the old animals, supplementation reversed the age-related decrease in ascorbate content in heart and liver cells. It also improved the ascorbate content in the cells of young animals. Lipoic acid supplementation also reversed the accumulation of iron in the brain cells of the old animals.

In conclusion, we found that aging impaired mitochondrial and cellular function of the liver, heart, and brain cells. The results of our dietary studies indicate that supplementation with acetylcarnitine and lipoic acid may retard or reverse this impairment.

This research was supported by the National Institute of Aging.

2-AEP is a component of the outer cell membrane.

Hormones

Many hormone levels decline with aging. In some instances, hormone replacement therapy may be quite beneficial, especially when combined with individual detoxification, nutrition, and regeneration support. Some of the important anti-aging hormones are:

• 7-Keto repletes hypo adrenal states without directly increasing sex hormone levels.
• DHEA is the precursor of many hormones, including progesterone.
• Estrogen replacement therapy is not generally recommended by most holistic practitioners. When needed, natural forms such as Triest are most biocompatible. Phytoestrogens are often a better choice for therapy.
• HGH: In 1990, Dr. Daniel Rudman published his human growth hormone research studies on the effects of longevity and life extension with Hgh in the New England Journal of Medicine. Six months of HGH injections reversed the aging process between 10 and 20 years. HGH is available in oral homeopathic forms. Growth hormone can directly reverse some aging effects, improve muscle strength and mass, reduce wrinkles and sagging skin, and decrease joint pain and inflammation. Consider supplementing HGH, or boosting levels with releasers.
• Pregnenolone is the precursor of DHEA.
• Progesterone is often used as a cream but is also available as oral drops in a base of Vitamin E for better absorption.

Exercise

Physical activity can prevent or delay the onset of hypertension, obesity, heart disease, falls, and osteoporosis. Rebound exercise is the most efficient and gentle exercise for every cell in the body.

Detox

Detoxify your blood and your liver seasonally, about four times a year. Personally tailored programs are the safest and most effective. These may include parasite, colon, kidney, or other organ cleanses as well as support for necessary rejuvenation. Sanum remedies can be very powerful for blood cleansing and immune regulation.

Hygiene

Slowing and Correction of the Aging Process

Kenneth E. Seaton, D. Sc., Howard Hall, Ph.D., Psy. D.

Overactivation of the immune system may result in elevated inflammatory and immune proteins potentially leading to reduced carrier proteins, particularly albumin, setting a biochemical environment associated with sub-optimal aging. Advanced personal hygiene may be an effective way to reduce this stress on the immune system/biochemistry and physiology. Cleanliness may be next to godliness, scientifically after all!

Hippocrates (400BC) presented a very astute description of the aging process where he noted; “ Old humans suffer difficulty of breathing, catarrh, coughing, strangury, passing urine, the pain of joints, kidney disease, dizziness, stroke, ill health with wasting, itchiness, sleeplessness, water discharge from bowels, nose & eyes, cataracts, and hardness of hearing”. An answer to all these problems may simply be better hygiene. Humans may be able to reach a longer life span of years in order to learn, experience, and gain the necessary wisdom to understand this world. Better hygiene may slow, and reverse to some degree, the aging process and many of its physical problems.

It may also be possible to reduce wrinkling of the skin, loss of hair, dimming of the vision, dementia, wasting, changes in the biochemistry, and loss of immunological performance, which was once considered a fundamental part of aging. This article will present the argument that better hygiene may address some of these problems and slow aging.

Many species of fish, dolphins, whales, seabirds and other creatures reach their maximum life span, looking much as they did when they were younger, avoiding to an amazing degree many of the physical problems that we humans think are normal in aging. Is the secret simple hygiene because of their life in the water? Occam’s razor confirms that the simplest solution is usually correct.

A paradox is the extreme rapid aging of the pacific salmon, after spawning, which is equivalent to the last 40 years of our lives, occurring in the fish in only a few days. Rapid aging in the salmon is caused by a massive production of the stress hormone cortisol, at the same time, there is a major reduction in albumin and cortisol binding globulin. (1) This biochemical stress process also is associated with the rapid aging of the marsupial mouse, octopus, and several other creatures’ (1) including humans (See photos). There is a photo of the rapid aging of a 25-yr-old woman in Cecil’s textbook of Med 20th ed. 1996 at p 1216.

How is this stress linked to hygiene? The buffer against free damaging cortisol is the concentration of albumin in body fluids (1). Albumin can bind over 1000 times the capacity of the Cortisol Binding Globulin (CBG) (1), thus the higher the concentration of albumin, which is also accompanied by a rise in CBG; the better buffered the animal is against stress & aging. (1) The stress on the immune system reduces carrier protein levels because it elevates defense/inflammatory proteins.

Carrying-capacity of the serum

The carrying capacity of serum appears to be a fundamental factor in aging (2). Osmotic pressure determines that when defense/inflammatory proteins are reduced naturally and safely, carrier proteins be raised. Albumin is the major carrier; a remarkable universal mother ship. This article will attempt to answer: (a) Is albumin the “Aging factor” or the “Life Factor”? (b) are albumin levels mainly determined via hygiene standards more than any other factor?

Dolphins age well

Data supplied by Dr. Jim McBain veterinary scientist from Sea World (see Chart) shows that there is no decline of albumin concentration in their aged dolphins, perhaps equivalent to 100 years in humans. The level of albumin normally falls in all aging animals. The level at Sea World over the decades appears to be increasing in accordance with better techniques of cleaning the water environment. The dolphins with higher albumin levels are also living longer and showing minimum signs of aging.

Stress

Edward Masoro, a distinguished aging researcher, presents the case that long-term low level and acute stresses play a role in the basis of aging (3). Dr. Masoro identifies that the exact levels of cortisol are important. Cortisol is also very beneficial, without it we would not be able to survive being late for work. Yet excess of this stress hormone damages the thymus, immune system, prevents repair, and unbalances the entire homeostasis.(4). Again the answer may be better hygiene to maintain very high albumin levels to ensure precise cortisol homeostasis despite the multitude of stresses encountered during the human life span. Accordingly, maintaining higher albumin levels may increase the life span.

Disease & stress

Illness is the most damaging form of stress. There is epidemiological evidence that low serum albumin levels are associated with increased risks of cancer and other diseases.(5) There is a fine line, almost indistinguishable between aging and disease. That fine line appears to be the reduction in albumin as it is the common denominator in both disease and aging.

No breakthrough in aging may occur until we maintain the entire homeostasis of biochemistry and physiology. Claude Bernard, the renowned physiologist, who taught at the Sorbonne and College de France summed up his research with his famous concept of Homeostasis which he called “ Milieu Interieur” (perfect interior environment). In support cells kept in a maximum lifespan, the experiment must have a perfect medium in the culture dish. The most important substance in the medium is the quality & quantity of albumin. (6)

You may swim, run, ski, work, make love, and sleep, all in conditions that vary dramatically. Yet all of the trillions of cells in your body must remain in very precise conditions of temperature, PH, chemical, and water balance. Even minute changes can cause damage, confusion even death. Maintaining this dynamic feedback and regulation between all the organs, blood, tissues and cells is homeostasis. Again the concentration of albumin in the blood and interstitial fluids is a remarkable buffer against dramatic and sudden changes. The answer to maintaining homeostasis is hygiene. Homeostasis may be maintained by special ion baths every night.

Senile dementia

There is no scourge more feared, no threat to independence greater, no rejection by friends more obvious, no shun by society more devastating, than the loss of mental competence that often accompanies aging. Any attempt to answer aging must include preventing senile dementia.

High concentrations of albumin in the serum are needed to ensure optimal levels in the brain and cerebral spinal fluid, vital for the security and performance of the CNS. Only 1/200-albumin molecules are specially selected to enter the CSF.(7) Albumin is also the amyloid degrading enzyme and the purifier. This may account for the relationship between intellectual standards and standard of hygiene/ albumin levels in civilizations. Long-term stresses, particularly chronic infections are linked to senile dementia. (7)

Three Factors

Three areas have been outlined for maintaining good health during the aging process: hygiene, diet & exercise. Also, each one of these supports and reinforces the other.

Diet

Repeated studies by labs & zoos around the world, over the last 50 years have consistently shown that the aging process can be slowed dramatically by restricting dietary calories. (8) The religious concept of fasting has a sound scientific basis. Unfortunately, dietary restriction is very difficult to implement and is unlikely to be a popular anti-aging practice, thus placing greater emphasis on hygiene and exercise. Dietary restriction (DR) and Hygiene appear to function in the same way; via reducing the stress on the serum to transport nutrients and wastes- DR reduces the food molecules that need to be carried, Hygiene reduces immune/inflammatory proteins making more room for carrier proteins.

There is increasing evidence linking infections to a tendency to overeat and infections causing the large abdomen. In addition, it takes lots of calories to run an overloaded immune system. Diabetes may even have a link to lower albumin and an over-stressed immune system(9).

Exercise

Exercise is very valuable, biochemically because it pumps and restores the connective tissue ensuring that nutrients reach cells and wastes products return to the blood. Exercise also ensures that serum proteins leave the blood and surround cells and finally neutralizes and transports toxic wastes through the lymphatic system. Serum proteins like albumin, besides transporting nutrients and wastes, are also used as a vital packet of amino acids for rebuilding and repair of the body that proceeds every day. The ability to repair correctly is a fundamental basis of optimal aging. The wasting in disease and aging is caused by insufficient albumin. Exercise in the presence of disease and stress on the immune system can have negative benefits. The combination of better hygiene and moderate exercise may provide the answer to how we achieve optimal health.

Hygiene

Hygiene is the newest discovery of the three basics. Only 150 years ago Semmelweis in Europe and Oliver Wendell Holmes Senior in the USA were ridiculed for educating doctors on the importance of handwashing before coming to the pregnancy ward. In those days it was acceptable for 1 in four women to die in childbirth. Today, because of the first steps in handwashing it is 1/100,000. Certainly, improvements in personal hygiene and living standards have been at the forefront of extending the average life expectancy from around 38 years in 1850 to 85 years in Japan & Australia today. (10)

Advanced hygiene

Advanced hygiene ensures the thumb/fingernails are cleaned automatically each time the hands are washed. The system also cleans the nasal passage, eyes, teeth, skin and hair. Overnight relief from respiratory and skin problems may occur. Serum albumin levels may also respond within days.

Results

After 20 years of experience with thousands of clients using the advanced hygiene system the majority report (a) reduction in respiratory, ear, nose, throat, and skin diseases, including allergies (b) Albumin of 43g/L A/G ratio of 1.6 rising to Albumin 48g/l A/G 2.0. This combination improvement suggests a life span increase of 25 years, namely 75years to 100 years. Each gram of albumin gained above the normal of 43g/L usually equates to 5 years increase in lifespan.

Super germs

We are just beginning to understand that germs live in colonies, like cities, perceive their environment, and adjust in a way to benefit them. Many produce toxins (venoms) far more powerful than any snake or spider, more than a match for any immune system. These clever germs are often “immunologically invisible” with proteins and sugars on their surface, identical to many of our own organ tissues. Infections with these common microbes regularly generate antibodies and T cells that cross-reacts and attack our own healthy tissues. This “ autoimmunity” plays a major role in aging and stress on the immune system.(11) Over the years of testing it has become clear that germs from under and around the fingernails, inside the nasal passage, and around the eyes are far more capable of causing disease in the host, and in larger concentrations (critical infecting dose) than the germs from the air of surfaces. This is one of the reasons why advanced hygiene may be effective.

Immune-Stress & Aging

The stress on the immune system from a combination of clever germs with their Superantigens mixed with environmental debris, continually self inoculated, and on the skin sets the scene for continual over activation of the immune system. This results in lifelong elevated inflammatory serum proteins termed “ Acute Phase Reactants”(APR’s). The liver produces these proteins when the immune system is under stress and the negative result is lower production of albumin, leading to high mortality, morbidity, and rapid aging. As it is often noted: “ you are as old as your immune system”.

Perhaps the most effective strategy to increase longevity is to prevent overstressing the immune system, thus keeping inflammatory and defense proteins and immune cells to the lowest healthy levels, so that the reduced osmotic pressure permits higher levels of albumin to be maintained, with anti-aging benefits. Hygiene may be the fundamental basis to achieving this anti-aging profile.

Biochemical Stress

Total proteins (g/L) Albumin Globulins A/G ratio Stress

63 28 35 0.8 Very high

67 37 30 1.23 High

70 41 29 1.41 Medium

71 43* 28 1.53 Normal

72 45 27 1.66 Minimum

73 50 23 2.2 Low

75 56 19 2.95 Optimal

* Average level in the USA

Cancer risks and stress on the biochemistry/physiology is high, descending from level 7 to level 1. Level 3 is the minimum profile that physicians should seek in all patients, regardless of age, race, or sex. Levels 1 and 2 have very low health and cancer risk. Levels 7 and 6 could be mistakenly associated with inadequate dietary protein. This study emphasizes hygiene standards need to be improved in levels 4 to 7. While a balanced diet is beneficial and should not be overlooked, only hygiene can naturally reduce the level of globulins, allowing more osmotic room for albumin.

Infections & free radicals

Reactive oxygen radical molecules that chemically bind with our tissues, aging them, are generated in large amounts, mainly during infections, overwhelming our anti-oxidant potential, regardless of any amount of anti-oxidant supplements. It is a “ devil’s circle” because over-activation of the immune system generates damaging free radicals and reduces albumin which is the “ 800 lb. gorilla” of all the other anti-oxidants combined. The albumin concentration is 4000 times higher than all other antioxidants combined. The anti-oxidant potential of serum depends on the concentration of albumin according to tests performed at Genox and Pantox laboratories. Hygiene may break this aging, mortality, morbidity “Devils Circle”.

Prevention of infection is a basic way to stop free radical damage. Free radicals are designed to kill germs. However, white cells are damaged and free radicals released, particularly in chronic disease, all at the time when albumin, the major anti-oxidant, is at its lowest. This is not the time to take plenty of anti-oxidants, as supplements may feed the germs and overload the liver, further reducing albumin.

Wastes

An important cause of aging is the toxic wastes that are naturally produced by every cell during its metabolic cycle. These wastes must be deactivated in the connective tissue before being allowed back into the blood, then safely transported to various sites for the final elimination. Overeating, infections, and over activation of the immune system, increase wastes, reduces albumin, and thus prevent proper neutralization and transport of wastes. Lower albumin and accumulation of waste products set the scene for instability and damage to cells leading to cancer (13). This may explain the mystery of why albumin is low in all cancers and why remission is associated with the restoration of albumin levels above 45g/l.

Immune system decline

Loss of immunological performance is well known in aging and is deeply involved with the shrinking of the thymus. This small gland above/ in front of the heart has been called the pacemaker of aging. Sir McFarlane Burnett proposed the thymus as the pacemaker in the 1950”s. The involution of the thymus must be arrested, to prevent loss of T cells and their performance, in any successful attempt to slow the aging process. Repeated and chronic infections and overstressing the immune system results in overproduction of cortisol and lower albumin leading to free cortisol cause involution of the thymus. There is a need to prevent too many, too severe, too chronic infections in order to preserve the thymus in old age. Hygiene may again be the answer.

Clues to premature aging

The positive results in those following the advanced hygiene system, commenced by Seaton in 1980, were the motivation for Seaton’s search for the secret of aging. The healthiest group of elderly people possible were studied and then compared to younger control subjects to see what differences there were in the biochemistry. Fortunately, many of these tests have been going on in aging laboratories, including the National Institute of Aging. The only real difference was a decline in albumin.

Plasma is the watery fraction of the blood including the clotting factor. The serum is the liquid without the clotting factors, and albumin is the most abundant (60%), versatile and complex soluble protein. In a healthy old person, the decline in albumin may only be .2 of a gram per deciliter (2 grams per liter). Yet, each gram lost is trillions of albumin transport ships. Albumin fits the aging jigsaw puzzle brilliantly because it has so many important roles. Albumin is the biochemical measure of stress and homeostasis. The lower the level, the greater the stress on the physiology. Albumin levels vary over a few days or months depending on the condition of the person at the time of measurement, explaining the good and bad days. When it is high we feel and look glowing, when it is low the opposite. Albumin concentration has emerged in all studies as the most powerful indicator of all-cause mortality and morbidity. (13 )

Albumin

It is the most studied yet least understood of all proteins. One of the reasons why it is needed is because the transport ability of the blood is critical to health and cells must receive nutrients, hormones, and electrolytes in the correct amount and at the right time. Albumin is also needed for cell growth and stability and long life. This was dramatically demonstrated in experiments where cells lasted 10 times longer, grew stronger and none converted to cancer lines when the medium contained the optimal quantity and quality of albumin (14). This study showed a profound benefit of increasing the quantity of highly purified albumin to the medium. Human cells continue to grow equivalent to over 150 years and none converted to cancer lines. Howard Green, today, is regarded as the leading authority in cell growth and is now at Harvard. It appears to be simply the” life factor.” Probably delivering and collecting electrons from cells, perhaps via nitric oxide, which it transports.

An example of albumin is the white of eggs or an important protein in milk. Unfortunately, high protein diets will not raise albumin levels while there is stress on the immune system. Infusion of albumin in hospitals to save lives following severe trauma may be warranted, however, there is often a negative outcome and this approach does not address the stress and globulin levels.

Albumin is the most abundant, dominant, versatile, and complex protein in body fluids, averaging a total of around 350g. Sixty percent of the serum proteins are albumin, with a mean USA level of around 42g/L (4.2g/dL). Optimal serum albumin levels for maximum life span are around 52-56g/L. Long regarded as the “Bellwether” of health, its many roles are just beginning to be understood, as follows:

• Cell growth. Maintenance of osmotic pressure. Body shape.
• Purification. Transport of many nutrients. High negative charge.
• Red blood cell stability. Transport of bilirubin. Solubility of uric acid
• Calcium transport. Thyroid hormone transport. Blood viscosity.
• Zeta potential. Fatty acid transport HDL/LDL ratios.
• Fat metabolism. Preventing Atherosclerosis. Protectingbloodvessels.
• Growth hormone homeostasis. Preventing stress. Sexhormonetransport.
• Electrolyte balance. Ph control. Protein synthesis.
• Radiation protection. Trauma protection. Blood volume.
• Connective tissue stability. Lymph function. Prevention of cancer.
• Dominant antioxidant. Iron transport. Serum solubility.
• Egg growth. Amniotic fluid function. Milk protein.
• Amino acid balance. Preventing drug overdose. Neutralizing toxins.
• Nitric oxide transport. Measure of evolution. Protecting the liver.
• Kidney function. Fetal development. Optimal pregnancy.
• Teeth development. Prevention of tooth decay. Protection of lungs.
• Maintenance of sperm. Preventing wrinkles. Maintaining eyesight.
• Cleaning the brain. Amyloid degrading. Stabilizing CSF.
• Transporting vitamin A. Transporting vitamin D. Homeostasis.
• Cortisol transport. Cleaning the kidneys. Immune function.

Albumin transport answers all Aging theories: Albumin easily answers the waste theory of aging, the free radical theory, the autoimmune theory, the cross-linking theory, the protein synthesis theory, ionizing theory, and the results achieved with calorie restriction. In summary, the multi-factorial evidence in aging is all answered by maintaining albumin levels around 50g/L, with an A/G ratio of 2.0.

Summary

“The genius learns from nature”. All eggs, seeds, fetuses, and brains are surrounded by a generous supply of albumin. At the commencement of lactation, milk contains especially high albumin levels. Cell growth requires optimal albumin. No other substance has so many roles or could possibly be the “Life Factor”. The major role of the liver is manufacturing albumin (1/2 a ton in a lifetime), and it also serves as a packet of perfect amino acids controlling the entire protein synthesis. Maintaining optimal albumin profiles can only be achieved by advanced hygiene techniques. Attempts to raise albumin by high protein diets, vitamins, minerals, herbs, supplements, and the infusion is the “Ultimate in metabolic misunderstanding”.

Conclusion

Basic hygiene practices only became widespread with the additions of bathrooms & soap in the middle of 1900. Hygiene increased lifespan from approximately 39 years in 1830 to over 70 years by 1980. It is reasonable to expect that advancements in hygiene will have a similar effect resulting in 100 years as normal. More important than maximum years is the robust condition that ensures from raising albumin and reducing globulins. High albumin through pregnancy and childhood ensures the optimal development and brain size, setting the scene for optimal aging and human development. Cleanliness is next to godliness, after all!

References

Seaton K, Micozzi M. Is Cortisol The Aging Hormone? J Adv. Med. 1998; 11: 73-94.

Seaton K . Carrying Capacity of Blood In Aging. Abstract Presented At Conference on Anti-Aging Medicine Las Vegas 1999 American Academy of Anti-Aging Medicine Dec 1999.

Masoro E. Hayflick Lecture 1996 Annual Meeting of American Aging Association Age 19:141-145 1996, Also Age News Spring 1998;27:1-4

Seaton K. Is Cortisol The Aging Hormone, Report of The National Hygiene Foundation Washington DC 1997

Steven Richard, Blumberg Baruch Serum Albumin and The Risk of Cancer Macronutrients Investigating Their Role in Cancer

Peters T All About Albumin Academic Press, San Diego1996

Seaton K. Albumin & Alzheimer’s. Age 1995; 18: 1-2

Walford R Maximum Lifespan. W. Norton & Co New York 1983

Schmidt M Et Al. Markers of Inflammation & Prediction of Diabetes, Lancet ;353:

Bourlie F, Vallery-Masson J Epidemiology & Ecology of Aging In Textbook of Geriatric Med Ed. Brocklehurst , Churchill Livingstone New York 1985 P 3-5

Walford R. The Immunologic Theory of Aging, Advances in Gerontological Research,2: 159-204 1967.

Seaton K. Health, Weath & Hygiene JNMA 1994;86:327

Goldwasser P, Feldman J . Association of Serum Albumin & Mortality , J. Clin Epidemiol 1997;50: 693-703

Todaro G, Green H. Albumin Supplemented Medium for Long-Term Cultivation of Cells. Proc Soc Exp Bio Med, 1964, 16, 688-692.